ddx24 Antibody (YA6847)
(Synonyms: DEAD (Asp-Glu-Ala-Asp) box helicase 24 antibody; ddx24 antibody; )ddx24 Antibody (YA6847) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ddx24.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, IF-Tissue
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Reactivity :
Zebrafish
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:50 |
Product Details
ddx24 Antibody (YA6847) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ddx24.
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Host Mouse
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Clonality Recombinant,Monoclonal
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Species ReactivityZebrafish
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Calculated Molecular Weight Predicted band size: 94.5 kDa
Recombinant protein within zebrafish ddx24 aa 562-819 / 832.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ddx24 is an ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA|(Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles[1][2][3][4].
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine
Induction: By type I interferons -
Isoforms & Post-Translational Modification
Q9GZR7 has two isomers: Q9GZR7-1: 96332 Da (predicted); Q9GZR7-2: 90298 Da (predicted).
Ubiquitinated by MDM2 without targeting DDX24 for proteasomal degradation -
Subunit
Interacts with FADD (PubMed:24204270)
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SwissProt ID
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Synonyms
DEAD (Asp-Glu-Ala-Asp) box helicase 24 antibody; ddx24 antibody;
Documentation
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