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DDX50 Antibody (YA8178)(PBS only)

(Synonyms: GU2; GUB; mcdrh; RH-II/GuB)

DDX50 Antibody (YA8178) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DDX50.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • DDX50 Antibody (YA8178)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-2000 1:800-1500

Product Details

Description

DDX50 Antibody (YA8178) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DDX50.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 82.4 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-287 of human DDX50 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    DDX50 is an ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta[1][2][3].

  • Subcellular Localization

    Nucleus, nucleolus,Cytoplasm

  • Expression


    Tissue_Specificity: Highest expression in skeletal muscle, liver, heart, placenta, and kidney

  • Isoforms & Post-Translational Modification

    Q9BQ39: 737 amino acids, molecular weight 82565 Da.

  • Subunit

    Interacts with C1QBP

  • SwissProt ID

    Q9BQ39

  • Synonyms

    GU2; GUB; mcdrh; RH-II/GuB

DDX50 Antibody (YA8178)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • DDX50 Antibody (YA8178)(PBS only) Product Image