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DHPS Antibody

(Synonyms: DS, DHPS, Deoxyhypusine synthase, DHS)

DHPS Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DHPS.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:1000-2000 1:100-200

Product Details

Description

DHPS Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DHPS.

  • Host Rabbit
  • Clonality Polyclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 45 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 40 kDa
Immunogen

Synthetic peptide corresponding to the center region of human DHPS.

Sensitivity

Endogenous

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    DHPS catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function[1].

  • Isoforms & Post-Translational Modification

    DHPS has 3 isoforms, P49366-1: amino acid length is 369, molecular weight is 40971 Da (predicted); P49366-2: amino acid length is 322, molecular weight is 35916 Da (predicted); P49366-3: amino acid length is 327, molecular weight is 36583 Da (predicted).DHPS 存在 3 个异构体，P49366-1：氨基酸个数为 369 个，分子量为 40971 Da (预测)；P49366-2：氨基酸个数为 322 个，分子量为 35916 Da (预测)；P49366-3：氨基酸个数为 327 个，分子量为 36583 Da (预测)。

  • Subunit

    Homotetramer formed by a dimer of dimers

  • SwissProt ID

    P49366

  • Gene ID
    1725 [NCBI]
  • Synonyms

    DS, DHPS, Deoxyhypusine synthase, DHS

[1]. Ganapathi M, et al. Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder. Am J Hum Genet. 2019 Feb 7;104(2):287-298. [Content Brief]

DHPS Antibody Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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