DHPS - deoxyhypusine synthase Gene

Also Known as DS; DHS; MIG13; NEDSSWI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1725

About DHPS

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,672,470-12,681,880 (from NCBI)

This gene has 22 transcripts (splice variants), 221 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 15.4), brain (RPKM 14.5) and 25 other tissues.

Summary

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

DHPS Products (6)

mRNA	Protein	Name
NM_001206974.2	NP_001193903.1	deoxyhypusine synthase isoform d
NM_001369691.1	NP_001356620.1	deoxyhypusine synthase isoform e
NM_001369692.1	NP_001356621.1	deoxyhypusine synthase isoform f
NM_001369693.1	NP_001356622.1	deoxyhypusine synthase isoform g
NM_001930.4	NP_001921.1	deoxyhypusine synthase isoform a
NM_013406.3	NP_037538.1	deoxyhypusine synthase isoform b

DHPS Protein Structure

0
100
200
300
369 a.a.

Protein Preferred Names	Protein Names
deoxyhypusine synthase	migration-inducing gene 13

DHPS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DHPS	P49366	RAB27B	Homo sapiens	O00194	Y2H Array	25416956
Intra	DHPS	P49366	RAB27B	Homo sapiens	O00194	Validated Y2H	25416956
Intra	DHPS	P49366	ZNF138	Homo sapiens	P52744-2	Validated Y2H	25416956
Intra	DHPS	P49366	ZNF138	Homo sapiens	P52744-2	Y2H Array	25416956
Intra	DHPS	P49366	ZNF138	Homo sapiens	P52744	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	ZNF138	Homo sapiens	P52744	Validated Y2H	32296183
Intra	DHPS	P49366	ZNF138	Homo sapiens	P52744	Y2H Array	32296183
Intra	DHPS	P49366	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	DHPS	P49366	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	DHPS	P49366	PTPRH	Homo sapiens	Q9HD43	Y2H Array	25416956
Intra	DHPS	P49366	PTPRH	Homo sapiens	Q9HD43	Y2H Prey Pooling	25416956
Intra	DHPS	P49366	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	DHPS	P49366	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	DHPS	P49366	RBP1	Homo sapiens	P09455	Y2H Array	32296183
Intra	DHPS	P49366	RBP1	Homo sapiens	P09455	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	DHPS	P49366	RPL9	Homo sapiens	P32969	Y2H Pooling	16189514
Intra	DHPS	P49366	RPL9	Homo sapiens	P32969	Validated Y2H	25416956
Intra	DHPS	P49366	RPL9	Homo sapiens	P32969	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	RPL9	Homo sapiens	P32969	Y2H Array	25416956
Intra	DHPS	P49366	RPL9	Homo sapiens	P32969	Y2H Array	32296183
Intra	DHPS	P49366	EIF5A	Homo sapiens	P63241	Validated Y2H	32296183
Intra	DHPS	P49366	EIF5A	Homo sapiens	P63241	Y2H Array	25416956
Intra	DHPS	P49366	EIF5A	Homo sapiens	P63241	Y2H Array	32296183
Intra	DHPS	P49366	EIF5A	Homo sapiens	P63241	Y2H Prey Pooling	25416956
Intra	DHPS	P49366	EIF5A	Homo sapiens	P63241	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	DHPS	P49366	MAPK3	Homo sapiens	P27361	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	MAPK3	Homo sapiens	P27361	Y2H Array	32296183
Intra	DHPS	P49366	NUDT18	Homo sapiens	Q6ZVK8	Y2H Array	19060904
Intra	DHPS	P49366	NUDT18	Homo sapiens	Q6ZVK8	Y2H Pooling	16189514
Intra	DHPS	P49366	NUDT18	Homo sapiens	Q6ZVK8	Y2H Pooling	19060904
Intra	DHPS	P49366	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	19060904
Intra	DHPS	P49366	NIF3L1	Homo sapiens	Q9GZT8	Y2H Pooling	19060904
Intra	DHPS	P49366	NIF3L1	Homo sapiens	Q9GZT8	Y2H Pooling	16189514
Intra	DHPS	P49366	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	DHPS	P49366	EIF5A2	Homo sapiens	Q9GZV4	Y2H Pooling	16189514
Intra	DHPS	P49366	EIF5A2	Homo sapiens	Q9GZV4	Validated Y2H	32296183
Intra	DHPS	P49366	EIF5A2	Homo sapiens	Q9GZV4	Y2H Array	25416956
Intra	DHPS	P49366	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	DHPS	P49366	PAX6	Homo sapiens	P26367	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DHPS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70038	Deoxyhypusine synthase/DHS Protein, Human (His)	P49366 (M1-D369)	≥ 95%, as determined by reducing SDS-PAGE.

DHPS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810866	DHPS Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Seizures And Speech And Walking Impairment	NEDSSWI
Pneumocystosis	Pneumocystis Jirovecii Pneumonia Pneumocystis Carinii Pneumonia Pneumocystis Pneumonia Pulmonary Pneumocystosis PCP Pneumocystosis Pneumonia Pneumonia Pneumocystis Carinii Pneumonia, Pneumocystis Pneumocystis Jiroveci Pneumonia
Plasmodium Falciparum Malaria	Falciparum Malaria Malaria, Falciparum Malaria Fever, Subtertian Malignant Tertian Fever Malaria Falciparum Cerebral Malaria Nos Cerebral Malaria
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Whipple Disease	Intestinal Lipodystrophy Whipple'S Disease Intestinal Lipophagic Granulomatosis Secondary Non-Tropical Sprue Tropheryma Whippelii Infection Whipples Disease
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Cystoisosporiasis	Isosporiasis Infection By Isospora Belli And Isospora Hominis Isosporosis Infection By Isospora Belli Or Isospora Hominis Isospora Belli Or Hominis Infection Coccidial Infestation Coccidiosis Coccidial Dysentery Intestinal Coccidiosis Nos
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Plasmodium Vivax Malaria	Malaria, Vivax Malaria By Plasmodium Vivax Vivax Malaria Malaria Vivax
Meningococcal Infection	Meningococcal Disease Meningococcal Infections Neisseria Meningitidis Infection Meningococcal Diseases Meningococcus Infection Due To Neisseria Meningitidis Meningococcal Disease Nos Meningococcal Infection Nos
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0273	Sulfadiazine	Inhibitor	99.89%	Yes
HY-B0212	Sulfapyridine	Inhibitor	99.85%	Yes
HY-B0273A	Sulfadiazine sodium	Inhibitor	98.0%	Yes
HY-B0212R	Sulfapyridine (Standard)	Inhibitor	99.86%	Unkown
HY-B0273R	Sulfadiazine (Standard)	Inhibitor	99.84%	Unkown
HY-B0273AR	Sulfadiazine sodium (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106927	Bay Y5959	Agonist	/	Phase 2
HY-106808	Cerebrocrast	Inhibitor	99.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108314A	GC7 Sulfate	Inhibitor	98.0%	Unkown
HY-115712	DHPS-IN-1	Inhibitor	99.78%	Unkown
HY-135218A	AV-153 free base	Activator	99.59%	Unkown
HY-W761300	1-(4-Pip-Ph)-DHP-dione		99.04%	Unkown
HY-B0273S	Sulfadiazine-d4	Inhibitor	99.31%	Unkown
HY-101390	(+)-Niguldipine hydrochloride	Ligand	98.06%	Unkown
HY-108314	GC-7	Inhibitor	/	Unkown
HY-161027	2,6-Didehydropeperomin B		/	Unkown
HY-RS03737	DHPS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W011231	DHP-050		98.58%	Unkown
HY-B0612DS1	Lercanidipine-d3 hydrochloride	Inhibitor	98.26%	Unkown
HY-106832	Vatanidipine	Antagonist	/	Unkown
HY-106832A	Vatanidipine hydrochloride	Antagonist	/	Unkown
HY-117090	(rac)-AL-37350A	Agonist	/	Unkown
HY-135218	AV-153	Activator	/	Unkown
HY-147721	Dihydropteroate synthase-IN-1	Inhibitor	/	Unkown
HY-155804	RIP1 kinase inhibitor 8	Inhibitor	/	Unkown
HY-175828	DHPS-IN-2	Inhibitor	/	Unkown
HY-182529	DHPS-IN-3		/	Unkown
HY-184113	Dihydropelitinib		/	Unkown
HY-B0273S1	Sulfadiazine-13C6	Inhibitor	99.18%	Unkown
HY-B0612AS	Lercanidipine-13C,d3 hydrochloride		/	Unkown
HY-B0612AS1	Lercanidipine-13C,d3-1 hydrochloride	Inhibitor	/	Unkown
HY-N18471	5,7-Dihydroxytryptamine	Ligand	/	Unkown
HY-106766	DHP-218	Antagonist	/	Unkown
HY-111282	MK-789	Antagonist	/	Unkown
HY-120411	Sadopine	Modulator	/	Unkown
HY-126171	Hypusine		/	Unkown
HY-135062	9-Methylguanine	Inhibitor	/	Unkown
HY-172109	DNA Gyrase-IN-15	Inhibitor	/	Unkown
HY-B0273B	Sulfadiazine 100 µg/mL in methanol	Inhibitor	99.68%	Unkown
HY-RS18754	Dhps Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25241	Dhps Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DHPS	VGNC	VGNC:39931
Felis catus	DHPS	VGNC	VGNC:78438
Mus musculus	DHPS	MGD	MGI:2683592
Bos taurus	DHPS	VGNC	VGNC:28038
Macaca mulatta	DHPS	VGNC	VGNC:71795
Rattus norvegicus	DHPS	RGD	RGD:1303326
Others	DHPS	NCBI