Bay Y5959
Bay Y5959 is a potent calcium channel agonist. Bay Y5959 binds to the DHP receptor in a voltage-dependent manner increases both the mean open time and the mean closed time of the Ca-channel. Bay Y5959 has the potential for the research of congestive heart failure, arrhythmic.
For research use only. We do not sell to patients.
- CAS No.: 146136-94-9
- Formula: C26H24N4O2
- Molecular Weight:424.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 146136-94-9
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Molecular Weight 424.49
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Formula C26H24N4O2
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SMILES
CC(C)OC(C1=C(N)NC(C)=C(C#N)[C@H]1C2=CC=CC3=C2C=C(C4=CC=CC=C4)C=N3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Purity & Documentation
References
[1]. Pu J, et al. Effects of Bay Y5959 on Ca2+ currents and intracellular Ca2+ in cells that have survived in the epicardial border of the infarcted canine heart. J Cardiovasc Pharmacol. 1999 Jun;33(6):929-37. [Content Brief]
[2]. Bechem M, et al. A new type of Ca-channel modulation by a novel class of 1,4-dihydropyridines. Life Sci. 1997;60(2):107-18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bay Y5959 Related Classifications
HY-106927 Related Classifications
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