146136-94-9
Chemical Structure
Bay Y5959
- CAS No.: 146136-94-9
- Formula:C26H24N4O2
- Molecular Weight:424.49
IUPAC Name: isopropyl (R)-2-amino-5-cyano-6-methyl-4-(3-phenylquinolin-5-yl)-1,4-dihydropyridine-3-carboxylate
InChIKey: PHJVBZVDUNTGNR-HSZRJFAPSA-N
SMILES: CC(C)OC(C1=C(N)NC(C)=C(C#N)[C@H]1C2=CC=CC3=C2C=C(C4=CC=CC=C4)C=N3)=O
Biological Activity: Bay Y5959 is a potent calcium channel agonist. Bay Y5959 binds to the DHP receptor in a voltage-dependent manner increases both the mean open time and the mean closed time of the Ca-channel. Bay Y5959 has the potential for the research of congestive heart failure, arrhythmic[1][2].
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Bay Y5959 | Bay Y5959 is a potent calcium channel agonist. Bay Y5959 binds to the DHP receptor in a voltage-dependent manner increases both the mean open time and the mean closed time of the Ca-channel. Bay Y5959 has the potential for the research of congestive heart failure, arrhythmic. | |||||||||||||||||||||
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- [1]. Pu J, et al. Effects of Bay Y5959 on Ca2+ currents and intracellular Ca2+ in cells that have survived in the epicardial border of the infarcted canine heart. J Cardiovasc Pharmacol. 1999 Jun;33(6):929-37. [Content Brief]
- [2]. Bechem M, et al. A new type of Ca-channel modulation by a novel class of 1,4-dihydropyridines. Life Sci. 1997;60(2):107-18. [Content Brief]
Keywords
