DOCK4 Antibody
(Synonyms: KIAA0716, DOCK4, Dedicator of cytokinesis protein 4)DOCK4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to DOCK4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol and 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:50-200 | 1:50-200 |
Product Details
DOCK4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to DOCK4.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 225 kDa
Synthetic peptide of Human DOCK4 (aa 1917-1966).
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol and 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DOCK4 acts as a guanine nucleotide exchange factor (GEF), promoting the exchange of GDP and GTP, converting inactive GDP-binding small GTPases into active GTP-binding forms. DOCK4 participates in the regulation of intercellular adhesion junctions. DOCK4 plays a role in cell migration. Isomer 2: Has higher guanine nucleotide exchange factor activity compared to other isomers.
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Subcellular Localization
Cell membrane, Cell projection, Cytoplasm, cytosol
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Expression
Tissue specificity: Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.
Isoform 2: May be specifically expressed in the brain and eye. -
Isoforms & Post-Translational Modification
DOCK4 has four isomers: Q8N1I0-1: 1966 amino acids, molecular weight 225,206 Da (predicted); Q8N1I0-2: 1937 amino acids, molecular weight 222,218 Da (predicted); Q8N1I0-3: 1975 amino acids, molecular weight 226,178 Da (predicted); Q8N1I0-4: 279 amino acids, molecular weight 29,833 Da (predicted).
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Subunit
Interacts with nucleotide-free Rap1; functions as a guanine nucleotide exchange factor (GEF) for Rap1. Interacts (via DOCKER domain) with RAC1; functions as a guanine nucleotide exchange factor (GEF) for RAC1. Interacts with the SH3 domain of CRK. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2. Interacts with USH1C (via PDZ 1 domain).
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SwissProt ID
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Synonyms
KIAA0716, DOCK4, Dedicator of cytokinesis protein 4
Documentation
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