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Cat. No.: HY-P87938

Drosha Antibody (YA7623)

Drosha Antibody (YA7623) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Drosha.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay	IP IP: Immunoprecipitation
Dilution Ratio	1:200-1:1000	1:2000-1:10000	1:200-1:1000	1:5000-1:20000	1:50-1:200

Description

Drosha Antibody (YA7623) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Drosha.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 159 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 159 kDa

Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG,Kappa

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Drosha is a Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons
Subcellular Localization

Nucleus,Nucleus, nucleolus,Cytoplasm
Expression

Tissue_Specificity: Ubiquitous
Isoforms & Post-Translational Modification

Q9NRR4 has four isomers: Q9NRR4-1: 159316 Da (predicted); Q9NRR4-2: 151296 Da (predicted); Q9NRR4-3: 138157 Da (predicted); Q9NRR4-4: 155333 Da (predicted).
Degraded by autophagy in response to neuronal activity in motor neurons
Subunit

Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:26027739, PubMed:26748718)
SwissProt ID

Q9NRR4