ERLIN1 Antibody (YA8401)
(Synonyms: C10orf69; Erlin-1; KE04; KEO4; SPFH1; SPG62)ERLIN1 Antibody (YA8401) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ERLIN1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:2000-2500 |
Product Details
ERLIN1 Antibody (YA8401) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ERLIN1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 39 kDa
Human recombinant protein fragment corresponding to amino acids 107-346 of human ERLIN1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ERLIN1 component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex |(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine -
Isoforms & Post-Translational Modification
O75477: 348 amino acids, molecular weight 39171 Da.
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Subunit
Forms a heteromeric complex with ERLIN2 (PubMed:19240031)
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SwissProt ID
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Synonyms
C10orf69; Erlin-1; KE04; KEO4; SPFH1; SPG62
Documentation
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