ERLIN1 Antibody (YA8401)

Cat. No.: HY-P88717: Data Sheet User Guide for Antibodies
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ERLIN1 Antibody (YA8401) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ERLIN1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ERLIN1 Antibody (YA8401) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ERLIN1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 39 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O75477

Immunogen

Human recombinant protein fragment corresponding to amino acids 107-346 of human ERLIN1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2000-2500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (PubMed:37683630). Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618)|(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production

Subcellular Localization：Endoplasmic reticulum membrane

Expression：
Tissue_Specificity: Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine

Isoforms & Post-Translational Modification：O75477: 348 amino acids, molecular weight 39171 Da.

Subunit：Forms a heteromeric complex with ERLIN2 (PubMed:19240031)

Synonyms

C10orf69; Erlin-1; KE04; KEO4; SPFH1; SPG62

Documentation

User Guide for Antibodies (1077 KB)