EXOSC9 Antibody (YA6562)
(Synonyms: Autoantigen PM/Scl 1 antibody; EXOS9_HUMAN antibody; EXOSC 9 antibody; EXOSC9 antibody; Exosome complex component RRP45 antibody; Exosome complex exonuclease RRP45 antibody; Exosome component 9 antibody; p5 antibody; p6 antibody; P75 polymyositis scleroderma overlap syndrome associated autoantigen antibody; Autoantigen PM/Scl 1 antibody; EXOS9_HUMAN antibody; EXOSC 9 antibody; EXOSC9 antibody; Exosome complex component RRP45 antibody; Exosome complex exonuclease RRP45 antibody; Exosome component 9 antibody; p5 antibody; p6 antibody; P75 polymyositis scleroderma overlap syndrome associated autoantigen antibody; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody; PM/Scl 75 antibody; PM/Scl-75 antibody; PMSCL autoantigen 75kD antibody; PMSCL1 antibody; Polymyositis/scleroderma autoantigen 1 75kDa antibody; Polymyositis/scleroderma autoantigen 1 antibody; Polymyositis/scleroderma autoantigen 75 kDa antibody; RRP45 antibody; Rrp45p antibody; )EXOSC9 Antibody (YA6562) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EXOSC9.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:2000 |
Product Details
EXOSC9 Antibody (YA6562) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EXOSC9.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Recombinant protein within human EXOSC9 aa 1-350.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EXOSC9 is a Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs
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Subcellular Localization
Cytoplasm,Nucleus,Nucleus, nucleolus,Nucleus, nucleoplasm,Nucleus, nucleolus,Nucleus, nucleolus,Nucleus
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Isoforms & Post-Translational Modification
Q06265 has four isomers: Q06265-1: 48949 Da (predicted); Q06265-2: 50803 Da (predicted); Q06265-3: 39235 Da (predicted); Q06265-4: 41089 Da (predicted).
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Subunit
Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC3, EXOSC4, EXOSC5 and DIS3 (PubMed:29906447, PubMed:30047866)
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SwissProt ID
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Synonyms
Autoantigen PM/Scl 1 antibody; EXOS9_HUMAN antibody; EXOSC 9 antibody; EXOSC9 antibody; Exosome complex component RRP45 antibody; Exosome complex exonuclease RRP45 antibody; Exosome component 9 antibody; p5 antibody; p6 antibody; P75 polymyositis scleroderma overlap syndrome associated autoantigen antibody; Autoantigen PM/Scl 1 antibody; EXOS9_HUMAN antibody; EXOSC 9 antibody; EXOSC9 antibody; Exosome complex component RRP45 antibody; Exosome complex exonuclease RRP45 antibody; Exosome component 9 antibody; p5 antibody; p6 antibody; P75 polymyositis scleroderma overlap syndrome associated autoantigen antibody; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody; PM/Scl 75 antibody; PM/Scl-75 antibody; PMSCL autoantigen 75kD antibody; PMSCL1 antibody; Polymyositis/scleroderma autoantigen 1 75kDa antibody; Polymyositis/scleroderma autoantigen 1 antibody; Polymyositis/scleroderma autoantigen 75 kDa antibody; RRP45 antibody; Rrp45p antibody;
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