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  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. F12 Antibody (YA7927)(PBS only)

F12 Antibody (YA7927)(PBS only)

Cat. No.: HY-P88243A
User Guide for Antibodies Technical Support

F12 Antibody (YA7927) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to F12.

For research use only. We do not sell to patients.

Size Stock
50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

F12 Antibody (YA7927) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to F12.
Host

Mouse
Species Reactivity
Human
SwissProt ID
Immunogen

Human recombinant protein fragment corresponding to amino acids 73-372 of human F12 produced in E.coli.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:150-500
Purity Affinity purified Conjugation Non-conjugated
Isotype IgG1  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (PubMed:2019570, PubMed:21304106, PubMed:8427954)
Subcellular Localization：Secreted
Isoforms & Post-Translational Modification：P00748: 615 amino acids, molecular weight 67792 Da.
Subunit：Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation
Synonyms
HAE3; HAEX; HAF
Documentation
User Guide for Antibodies (1077 KB)

F12 Antibody (YA7927)(PBS only) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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F12 Antibody (YA7927)(PBS only)
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