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FAAH1 Antibody (YA2064)

(Synonyms: FA2H; FAAH; FAAH-1; Oleamide hydrolase 1; Oleamide hydrolase)
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FAAH1 Antibody (YA2064) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAAH1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • FAAH1 Antibody (YA2064) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:1000-1:2000 1:50-1:100

Product Details

Description

FAAH1 Antibody (YA2064) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAAH1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 63 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 63 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human FAAH1 aa500-579/579.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    FAAH-1 (fatty acid amide hydrolase-1) is a membrane-associated serine hydrolase that terminates endocannabinoid signaling by hydrolyzing anandamide and other bioactive fatty acid amides, thereby regulating their tissue concentration and biological activity[1][2]. Mechanistically, FAAH-1 functions as a major catabolic enzyme within the endocannabinoid pathway and controls the magnitude and duration of lipid-mediated signaling processes relevant to neuronal, inflammatory, and peripheral physiological responses[1][3]. Experimental studies demonstrated that loss of FAAH activity enhances endogenous cannabinoid signaling and increases sensitivity to anandamide, establishing FAAH-1 as a critical regulator of endocannabinoid homeostasis in vivo[4]. In disease-relevant and pharmacological models, modulation of FAAH activity has therefore been widely used to investigate pain, neuroinflammation, and other endocannabinoid-dependent biological processes[3][4]. Compared with the related isoform FAAH-2, FAAH-1 exhibits substantially greater catalytic activity toward N-acyl ethanolamines, including anandamide, and toward N-acyl taurines, highlighting a distinct substrate preference within fatty acid amide metabolism[5]. FAAH-1 and FAAH-2 also display overlapping but distinct tissue distributions, suggesting complementary roles in controlling fatty acid amide catabolism in primates[5]. For experimental applications, selective FAAH inhibitors such as URB597, PF-3845, and related compounds are extensively employed to elevate endogenous fatty acid amide levels and probe endocannabinoid signaling mechanisms, making FAAH-1 a well-established pharmacological target for mechanistic research[2][3].

  • Subcellular Localization

    Endomembrane system; Single-pass membrane protein; Cytoplasm, cytoskeleton

  • Expression


    Tissue_specificity:Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate

  • Subunit

    Homodimer

  • SwissProt ID

    O00519

  • Gene ID
    2166 [NCBI]
  • Synonyms

    FA2H; FAAH; FAAH-1; Oleamide hydrolase 1; Oleamide hydrolase

  • Research Field

    Signal Transduction

[1]. Dainese E, et al. The endocannabinoid hydrolase FAAH is an allosteric enzyme. Sci Rep. 2020 Feb 10;10(1):2292. [Content Brief]

[2]. van Egmond N, et al. Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors. Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:441-463. [Content Brief]

[3]. Lee MJ, et al. Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial. Lancet HIV. 2026 May 27:S2352-3018(26)00059-7. [Content Brief]

[4]. Cravatt BF, et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9371-6. [Content Brief]

[5]. Wei BQ, et al. A second fatty acid amide hydrolase with variable distribution among placental mammals. J Biol Chem. 2006 Dec 1;281(48):36569-78. [Content Brief]

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FAAH1 Antibody (YA2064) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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