FAAH - fatty acid amide hydrolase Gene

Also Known as PSAB; FAAH-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2166

About FAAH

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,394,317-46,413,845 (from NCBI)

This gene has 6 transcripts (splice variants), 131 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in prostate (RPKM 30.1), thyroid (RPKM 21.8) and 23 other tissues.

Summary

This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

FAAH Products (1)

mRNA	Protein	Name
NM_001441.3	NP_001432.2	fatty-acid amide hydrolase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables fatty acid amide hydrolase activity	IDA IDA: Inferred from direct assay	9122178	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid catabolic process	IDA IDA: Inferred from direct assay	9122178	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAAH Protein Structure

Amidase

0
100
200
300
400
500
579 a.a.

Protein Preferred Names	Protein Names
fatty-acid amide hydrolase 1	anandamide amidohydrolase 1 fatty acid ester hydrolase oleamide hydrolase 1

FAAH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FAAH	O00519	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	FAAH	O00519	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

FAAH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82319	FAAH1 Antibody (YA2064)	WB, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Hallucinogen Dependence	Hallucinogen Addiction
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Constipation
Back Pain
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Smei Severe Myoclonic Epilepsy In Infancy Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Developmental And Epileptic Encephalopathy, 6 Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Vulvar Syringoma
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Polysubstance Abuse	Polysubstance Abuse, Susceptibility To Drug Addiction PSAB Drug Addiction, Susceptibility To Drug Dependence
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Drug Dependence
Cannabis Dependence	Marijuana Abuse Cannabinoid Addiction Cannabinoid Dependence Cannabis Addiction
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Pain Agnosia	Analgesia
Lennox-Gastaut Syndrome	Epileptic Encephalopathy Lennox-Gastaut Type Lennox Syndrome Encephalopathy Of Childhood Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Cannabis Abuse	Marijuana Abuse
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1227	Carprofen	Inhibitor	99.94%	Unkown
HY-B0182	Carmofur	Inhibitor	99.95%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14376	Redafamdastat	Inhibitor	98.86%	Phase 2
HY-177093	Irafamdastat	Inhibitor	98.07%	Phase 2
HY-123863	SSR411298	Inhibitor	99.75%	Phase 2
HY-124744	ASP 8477	Inhibitor	98.35%	Phase 2
HY-19636A	JNJ-42165279 dihydrochloride	Inhibitor	/	Phase 2
HY-10864	URB-597	Inhibitor	98.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (85)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14595	Biochanin A	Inhibitor	99.33%	Unkown
HY-119283	CAY10499	Inhibitor	99.58%	Unkown
HY-136924	FP-Biotin		99.08%	Unkown
HY-14380	PF-3845	Inhibitor	99.95%	Unkown
HY-15250	JZL195	Inhibitor	99.75%	Unkown
HY-10865	LY2183240	Inhibitor	98.04%	Unkown
HY-120961	Oleoyl ethyl amide	Inhibitor	99.9%	Unkown
HY-116477	URB937	Inhibitor	99.62%	Unkown
HY-19636	JNJ-42165279	Inhibitor	99.95%	Unkown
HY-155773	VU534	Inhibitor	98.10%	Unkown
HY-N2365	Macamide B	Inhibitor	99.35%	Unkown
HY-19740	BIA 10-2474	Inhibitor	98.74%	Unkown
HY-164495	Sob-AM2		98.5%	Unkown
HY-N2512	1-Monomyristin	Inhibitor	98.0%	Unkown
HY-N7062	JNJ-1661010	Inhibitor	99.77%	Unkown
HY-103462	TC-F2	Inhibitor	99.35%	Unkown
HY-125967	AM 374	Inhibitor	97.0%	Unkown
HY-131678	Palmitoyl serotonin	Antagonist	99.9%	Unkown
HY-163733	AKU-005	Inhibitor	99.48%	Unkown
HY-79511	FAAH-IN-2	Inhibitor	99.12%	Unkown
HY-18081	PF 750	Inhibitor	98.99%	Unkown
HY-10862	FAAH inhibitor 1	Inhibitor	98.30%	Unkown
HY-18544	AA38-3	Inhibitor	99.95%	Unkown
HY-103461	FAAH-IN-6	Inhibitor	99.70%	Unkown
HY-110138	PDP-EA	Activator	98.28%	Unkown
HY-77491	FAAH/MAGL-IN-5	Inhibitor	94.16%	Unkown
HY-N2428	N-(3-Methoxybenzyl)Palmitamide	Inhibitor	99.90%	Unkown
HY-103337	N-Arachidonoylserotonin	Inhibitor	99.11%	Unkown
HY-118158	FAAH/MAGL-IN-4	Inhibitor	99.83%	Unkown
HY-W751418	N-Nervonoyl taurine		99.0%	Unkown
HY-111389	FAAH-IN-1	Inhibitor	99.59%	Unkown
HY-18080	SA 47	Inhibitor	99.0%	Unkown
HY-111199	JP83	Inhibitor	99.0%	Unkown
HY-18013	JNJ-40355003	Inhibitor	99.81%	Unkown
HY-152254	CB2R/FAAH modulator-3	Inhibitor	99.71%	Unkown
HY-14595R	Biochanin A (Standard)	Inhibitor	98.74%	Unkown
HY-121558	JP104	Inhibitor	99.67%	Unkown
HY-N3033	N-Benzyllinolenamide	Inhibitor	99.70%	Unkown
HY-127023	Eicosapentaenoyl serotonin	Inhibitor	99.0%	Unkown
HY-103339	VDM11	Inhibitor	99.25%	Unkown
HY-148909	Isopropyl dodec-11-enylfluorophosphonate	Inhibitor	/	Unkown
HY-B1227S1	Carprofen-13C,d3		/	Unkown
HY-184331	FAAH-IN-10	Inhibitor	/	Unkown
HY-12909	MK-4409	Inhibitor	/	Unkown
HY-B1227S	Carprofen-d3	Inhibitor	/	Unkown
HY-120369	URB532	Inhibitor	/	Unkown
HY-10867	PF-622	Inhibitor	/	Unkown
HY-102054	Acetylhydrolase-IN-1	Inhibitor	/	Unkown
HY-146341	FAAH-IN-5	Inhibitor	/	Unkown
HY-138693	ST4070	Inhibitor	/	Unkown
HY-152253	CB2R/FAAH modulator-2	Inhibitor	/	Unkown
HY-116710	3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone	Inhibitor	/	Unkown
HY-103463	SA57	Inhibitor	≥99.0%	Unkown
HY-122159	MDPD	Activator	/	Unkown
HY-143264	FAAH/MAGL-IN-2	Inhibitor	/	Unkown
HY-175816	5-HT6R/FAAH modulator 1	Inhibitor	/	Unkown
HY-W728451	URB694	Inhibitor	/	Unkown
HY-183805	5-HT6R/FAAH modulator 2	Inhibitor	/	Unkown
HY-116798	URB524	Inhibitor	/	Unkown
HY-143263	FAAH/MAGL-IN-1	Inhibitor	/	Unkown
HY-147910	Carpro-AM1	Inhibitor	/	Unkown
HY-139143	WWL154	Inhibitor	98.96%	Unkown
HY-146342	FAAH/MAGL-IN-3	Inhibitor	/	Unkown
HY-182589	SRP-001	Inhibitor	/	Unkown
HY-151919	FAAH-IN-7	Inhibitor	/	Unkown
HY-149654	FAAH/cPLA2α-IN-1	Inhibitor	/	Unkown
HY-115004	MM-433593		/	Unkown
HY-152251	CB2R/FAAH modulator-1	Inhibitor	99.14%	Unkown
HY-157766	FAAH/TRPV1 blocker-1	Inhibitor	/	Unkown
HY-144738	Dual FAAH/sEH-IN-1	Inhibitor	/	Unkown
HY-168563	BuChE-IN-15	Inhibitor	/	Unkown
HY-111293	Arachidonamide		/	Unkown
HY-181463	20-Hydroxy-N-arachidonoyl taurine	Substrate	/	Unkown
HY-164506	NRMA-8	Modulator	/	Unkown
HY-120481	JNJ-40413269	Inhibitor	/	Unkown
HY-161965	MK-3168 (12C)	Inhibitor	/	Unkown
HY-10869	OL-135	Inhibitor	/	Unkown
HY-121090	FAAH-IN-9	Inhibitor	/	Unkown
HY-169603	AZ513	Inhibitor	/	Unkown
HY-139384	FAAH inhibitor 2	Inhibitor	99.44%	Unkown
HY-157132	FAAH-IN-8	Inhibitor	/	Unkown
HY-118210	PHOP	Inhibitor	/	Unkown
HY-158784	Arachidonoyl m-nitroaniline		/	Unkown
HY-120650	CAY10435	Inhibitor	/	Unkown
HY-U00240	SA72	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FAAH	VGNC	VGNC:56993
Bos taurus	FAAH	VGNC	VGNC:55171
Mus musculus	FAAH	MGD	MGI:109609
Rattus norvegicus	FAAH	RGD	RGD:61808
Felis catus	FAAH	VGNC	VGNC:62031
Others	FAAH	NCBI