AChE-IN-125
AChE-IN-125 is a potent and selective acetylcholinesterase (AChE) inhibitor with an IC50 of 9 nM against hAChE. AChE-IN-125 shows no obvious cytotoxicity against neuroblastoma cells. AChE-IN-125 can be used for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C21H25ClN4O4
- Molecular Weight:432.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
hAChE 9 nM (IC50) |
eqBCHE |
In Vitro
AChE-IN-125 (10 μM; 20 min) shows weak inhibition of eqBChE, producing 50% inhibition at 10 μM[1].
AChE-IN-125 (3-30 μM; 48 h) does not exhibit significant cytotoxicity toward SH-SY5Y cells at the tested concentrations[1].
AChE-IN-125 (10 μM; 30 min) weakly inhibits hFAAH activity, with an inhibition rate below 10%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y
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Concentration:3, 10, 30 μM
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Incubation Time:48 h
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Result:No significant cytotoxicity was observed up to 30 μM after 48 h.
Chemical Information
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Molecular Weight 432.90
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Formula C21H25ClN4O4
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SMILES
O=C(NCCN1CCN(CC2=CC=CC=C2)CC1)COC3=CC(Cl)=CC=C3[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-125 Related Classifications
HY-190851 Related Classifications
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