FBXO6 Antibody (YA8021)

Cat. No.: HY-P88337: Data Sheet User Guide for Antibodies
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FBXO6 Antibody (YA8021) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FBXO6.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

FBXO6 Antibody (YA8021) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FBXO6.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 33.8 kDa

Species Reactivity

Human

SwissProt ID

Q9NRD1

Immunogen

Full length human recombiant protein of human FBXO6 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication

Subcellular Localization：Cytoplasm

Isoforms & Post-Translational Modification：Q9NRD1: 293 amino acids, molecular weight 33933 Da.

Subunit：Interacts with VCP (By similarity)

Synonyms

FBG2; FBS2; FBX6; Fbx6b

Documentation

User Guide for Antibodies (1077 KB)