FERMT3 Antibody (YA8029)
(Synonyms: KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF)FERMT3 Antibody (YA8029) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FERMT3.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
FERMT3 Antibody (YA8029) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FERMT3.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 75.2 kDa
Human recombinant protein fragment corresponding to amino acids 259-528 of human FERMT3 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
FERMT3 plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs)|Isoform 2 may act as a repressor of NF-kappa-B and apoptosis[1][2][3].
-
Subcellular Localization
Cell projection, podosome
-
Expression
Tissue_Specificity: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies -
Isoforms & Post-Translational Modification
Q86UX7 has two isomers: Q86UX7-1: 75953 Da (predicted); Q86UX7-2: 75430 Da (predicted).
-
Subunit
Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails)
-
SwissProt ID
-
Synonyms
KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF
Documentation
Powered by Bioz
