FERMT3 Antibody (YA8029)

Cat. No.: HY-P88345: Ficha de datos User Guide for Antibodies
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FERMT3 Antibody (YA8029) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FERMT3.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

FERMT3 Antibody (YA8029) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FERMT3.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 75.2 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q86UX7

Immunogen

Human recombinant protein fragment corresponding to amino acids 259-528 of human FERMT3 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Pureza	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity)|Isoform 2 may act as a repressor of NF-kappa-B and apoptosis

Subcellular Localization：Cell projection, podosome

Expression：
Tissue_Specificity: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies

Isoforms & Post-Translational Modification：Q86UX7 has two isomers: Q86UX7-1: 75953 Da (predicted); Q86UX7-2: 75430 Da (predicted).

Subunit：Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails)

Synonyms

KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF

Documentación

User Guide for Antibodies (1077 KB)