FNDC4 Antibody (YA8622)
(Synonyms: FRCP1)FNDC4 Antibody (YA8622) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FNDC4.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-250 |
Product Details
FNDC4 Antibody (YA8622) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FNDC4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 25 kDa
Full length human recombinant protein of human FNDC4 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FNDC4 is a Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation. May suppress osteoclastogenesis and mature osteoclast resorptive function. In white adipose tissue, decreases local inflammation, via interaction with GPR116. Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake. The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling
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Subcellular Localization
Membrane,Secreted
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Expression
Tissue_Specificity: Highly expressed in the liver and the brain, including in the cortex, hypothalamus and hippocampus (PubMed:34016966). Also expressed in adipose tissue (PubMed:34016966)
Induction: Up-regulated by inflammation in the intestine (PubMed:27066907). Up-regulated by TGFB1 in a colorectal adenocarcinoma cell line -
Isoforms & Post-Translational Modification
Q9H6D8: 234 amino acids, molecular weight 25159 Da.
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SwissProt ID
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Synonyms
FRCP1
Documentation
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