Follistatin Antibody (YA9750)
(Synonyms: Activin binding protein, Activin-binding protein, Follistatin, FS, fst, FST_HUMAN, Human follistatin gene)Follistatin Antibody (YA9750) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Follistatin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Rat, Mouse
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:1000 |
Product Details
Follistatin Antibody (YA9750) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Follistatin.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Rat, Mouse
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Calculated Molecular Weight Predicted band size: 38 kDa;
Recombinant protein of human Follistatin (aa 1-150) 344.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Follistatin is a Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling. Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA[1][2][3].
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Subcellular Localization
Secreted; Nucleus, nucleolus
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Expression
Tissue_Specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme.
Induction: By glucose deprivation. -
Isoforms & Post-Translational Modification
Follistatin has 2 isoforms, P19883-1: amino acid length is 344, molecular weight is 38007 Da (predicted); P19883-2: amino acid length is 317, molecular weight is 34803 Da (predicted).
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Subunit
Interacts with GDF11.
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SwissProt ID
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Synonyms
Activin binding protein, Activin-binding protein, Follistatin, FS, fst, FST_HUMAN, Human follistatin gene
Documentation
References
[1]. Sidis Y, et al. Follistatin: essential role for the N-terminal domain in activin binding and neutralization. J Biol Chem. 2001 May 25;276(21):17718-26. [Content Brief]
[2]. Harrington AE, et al. Structural basis for the inhibition of activin signalling by follistatin. EMBO J. 2006 Mar 8;25(5):1035-45. [Content Brief]
[3]. Schneyer AL, et al. Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin. Endocrinology. 2008 Sep;149(9):4589-95. [Content Brief]
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