G-CSF Antibody (YA6402)
(Synonyms: GCSF; Colony stimulating factor 3(granulocyte); CSF 3; CSF beta; CSF3; Csfg; Filgrastim; GCSA; Granulocyte colony stimulating factor; Lenograstim; Macrophage granulocyte inducer 2; MGC45931; MGI 2; Pluripoietin; Granulocyte Colony Stimulating Factors 3; CSF3_HUMAN.)G-CSF Antibody (YA6402) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to G-CSF.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
G-CSF Antibody (YA6402) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to G-CSF.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 19 kDa
Recombinded human G-CSF protein aa
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Granulocyte colony stimulating factor (G-CSF; CSF 3) is a pro-inflammatory cytokine which primarily stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. Human G-CSF is secreted mainly by monocytes and macrophages, but is also produced by endothelial cells, fibroblasts, and bone marrow stromal cells. G-CSF binds and activates its cognate receptor G-CSFR on neutrophils and their progenitors, which initiates downstream signaling cascades that include the Jak-STAT and MAP kinase pathways. G-CSF is a major regulator of neutrophil development and contributes to the regulation of multipotent hematopoietic progenitors. In addition, G-CSF also influences the phenotype and function of mature neutrophils and does so by modulating expression of for example chemokine receptors, up-regulating phagocytosis and production of reactive oxygen species (ROS) and enhancing bactericidal activity of neutrophils. It is worth mentioning that G-CSF is an FDA- and EMA- approved drug commonly used to treat neutropenia and to mobilize bone marrow hematopoietic stem cells for transplantation.
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Subcellular Localization
Secreted
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Isoforms & Post-Translational Modification
P09919 has three isomers: P09919-1: 22293 Da (predicted); P09919-2: 21978 Da (predicted); P09919-3: 18434 Da (predicted).
O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells) -
Subunit
Monomer
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SwissProt ID
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Synonyms
GCSF; Colony stimulating factor 3(granulocyte); CSF 3; CSF beta; CSF3; Csfg; Filgrastim; GCSA; Granulocyte colony stimulating factor; Lenograstim; Macrophage granulocyte inducer 2; MGC45931; MGI 2; Pluripoietin; Granulocyte Colony Stimulating Factors 3; CSF3_HUMAN.
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