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Art. -Nr.: HY-P83309

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GARS Antibody (YA3054)

(Synonyms: HMN5; CMT2D; DSMAV; GlyRS; SMAD1)

GARS Antibody (YA3054) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GARS.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P
Reactivity :
Human, Mouse, Rat

Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Conjugation:
Non-conjugated

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Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio	1:500-1:1000	1:50-1:100

Product Details

Beschreibung

GARS Antibody (YA3054) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GARS.

Host Rabbit
Clonality Recombinant, Monoclonal
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 75 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 83 kDa

Species Reactivity Database

Entrez Gene: 2617 Human ; 353172 Mouse ; 297113 Rat

SwissProt: P41250 Human ; Q9CZD3 Mouse ; Q5I0G4 Rat

OMIM: 601472 Human

Immunogen

A synthesized peptide derived from human GARS aa701-739.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.

Background

Function

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017)
Subcellular Localization

Cytoplasm; Cell projection, axon; Secreted; Secreted, extracellular exosome; Mitochondrion; Cytoplasm; Cytoplasm; Cell projection, axon
Expression

Tissue_specificity:Widely expressed, including in brain and spinal cord; Expressed in brain, spinal cord, muscle, heart and spleen; Expressed in brain, spinal cord, muscle, heart, spleen and liver
Isoforms & Post-Translational Modification

P41250 has 2 isomers: P41250-1: 83166 Da (predicted); P41250-2: 77531 Da (predicted).
Subunit

Homodimer
SwissProt ID

P41250
Gene ID

2617 [NCBI]
Synonyms

HMN5; CMT2D; DSMAV; GlyRS; SMAD1
Research Field

Epigenetics and Nuclear Signaling