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GATA6 Antibody (YA757)

(Synonyms: GATA6; Transcription factor GATA-6; GATA-binding factor 6)
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GATA6 Antibody (YA757) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to GATA6.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

GATA6 Antibody (YA757) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to GATA6.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 60 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 60 kDa
Species Reactivity Database

Entrez Gene: 2627 Human

SwissProt: Q92908 Human

Immunogen

Synthetic peptide corresponding to Human GATA6.The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3102954

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    GATA6 transcriptional activator. Regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium. May regulate genes that protect epithelial cells from bacterial infection. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate[1][2][3][4][5][6][7].

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:It is expressed in the heart, intestine, and intestinal-derived tissues. It is also expressed in the pilosebaceous unit of the upper skin layer. Its expression is reduced or absent in acne lesions (PubMed:33082341) .

    Induction:In sebocytes, expression is up-regulated by Cutibacterium acnes

  • Isoforms & Post-Translational Modification

    Q92908 has 2 isomers: Q92908-1: 60033 Da (predicted); Q92908-2: 45386 Da (predicted).

  • Subunit

    Interacts with LMCD1

  • SwissProt ID

    Q92908

  • Gene ID
    2627 [NCBI]
  • Synonyms

    GATA6; Transcription factor GATA-6; GATA-binding factor 6

  • Research Field

    Epigenetics and Nuclear Signaling

[1]. Kodo K, et al. GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13933-8. [Content Brief]

[2]. Yang YQ, et al. GATA6 loss-of-function mutation in atrial fibrillation. Eur J Med Genet. 2012 Oct;55(10):520-6. [Content Brief]

[3]. Li J, et al. Novel GATA6 loss-of-function mutation responsible for familial atrial fibrillation. Int J Mol Med. 2012 Oct;30(4):783-90. [Content Brief]

[4]. Tucker NR, et al. Gain-of-function mutations in GATA6 lead to atrial fibrillation. Heart Rhythm. 2017 Feb;14(2):284-291. [Content Brief]

[5]. Yoshida T, et al. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. FEBS Lett. 1997 Sep 8;414(2):333-7. [Content Brief]

[6]. Shapira M, et al. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14086-91. [Content Brief]

[7]. Oulès B, et al. Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Nat Commun. 2020 Oct 20;11(1):5067. [Content Brief]

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GATA6 Antibody (YA757) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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