GRAF Antibody (YA6910)
(Synonyms: arhgap26 antibody)GRAF Antibody (YA6910) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRAF.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:200-1:1000 |
Product Details
GRAF Antibody (YA6910) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRAF.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 92 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size：92 kDa
Synthetic peptide within Human GRAF aa 750-814.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GRAF is a GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V |Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins[1][2].
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Subcellular Localization
Endosome membrane,Cytoplasm,Cell junction, focal adhesion,Cytoplasm, cytoskeleton
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Isoforms & Post-Translational Modification
Q9UNA1 has two isomers: Q9UNA1-1: 92235 Da (predicted); Q9UNA1-2: 86165 Da (predicted).
Phosphorylated in a PINK1-dependent fashion promoting retrograde mitochondrial trafficking and clustering -
Subunit
Interacts with NYAP1, NYAP2 and MYO16 (By similarity)
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SwissProt ID
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Synonyms
arhgap26 antibody
Documentation
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