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Cat. No.: HY-P86300

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Granzyme B Antibody (YA5992)

Name: Granzyme B Antibody (YA5992)
Brand: MedChemExpress
SKU: HY-P86300
Availability: PreOrder

(Synonyms: Granzyme B; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; )

Granzyme B Antibody (YA5992) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Granzyme B.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P, ICC/IF, IP, ELISA
Reactivity :
Human

Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Classifications
Bioz

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay	IP IP: Immunoprecipitation
Dilution Ratio	1:1000-1:4000	1:2000-1:10000	1:200-1:1000	1:5000-1:20000	1:50-1:200

Product Details

Description

Granzyme B Antibody (YA5992) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Granzyme B.

Host Rabbit
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 37 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 28 kDa

Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

Granzyme B is an Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair^[1]^[2]^[3]^[4]^[5]^[6]^[7].
Subcellular Localization

Secreted; Cytolytic granule
Expression

Induction:By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes
SwissProt ID

P10144
Gene ID

3002 [NCBI]
Synonyms

Granzyme B; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E;