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Cat. No.: HY-P87959

GRB7 Antibody (YA7644)

GRB7 Antibody (YA7644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRB7.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	IF-Tissue IF-Tissue: Immunofluorescence-Tissue
Dilution Ratio	1:500-2000	1:100-200	1:100-200	1:100-200

Description

GRB7 Antibody (YA7644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRB7.

Host Rabbit
Clonality Recombinant
Species Reactivity
Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
Observed Molecular Weight

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 60 kDa

Immunogen

A synthesized peptide derived from human GRB7

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

GRB7 is an Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress
Subcellular Localization

Cytoplasm,Cell junction, focal adhesion,Cell membrane,Cytoplasmic granule,Cell projection
Isoforms & Post-Translational Modification

Q14451 has four isomers: Q14451-1: 59681 Da (predicted); Q14451-2: 49423 Da (predicted); Q14451-3: 62064 Da (predicted); Q14451-4: 55920 Da (predicted).
Phosphorylated on serine and threonine residues in response to heregulin
Subunit

Homodimer
SwissProt ID

Q14451