GRB7 Antibody (YA7644)

Cat. No.: HY-P87959: Ficha de datos User Guide for Antibodies
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GRB7 Antibody (YA7644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRB7.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

GRB7 Antibody (YA7644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRB7.

Host

Rabbit

Clonality

Recombinant

Peso molecular

Predicted band size: 60 kDa;

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

Q14451

Immunogen

A synthesized peptide derived from human GRB7

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-200
IHC-F IHC-F: Immunohistochemistry-Frozen	1:100-200
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:100-200

Sensitivity	Endogenous	Pureza	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity)

Subcellular Localization：Cytoplasm,Cell junction, focal adhesion,Cell membrane,Cytoplasmic granule,Cell projection

Isoforms & Post-Translational Modification：Q14451 has four isomers: Q14451-1: 59681 Da (predicted); Q14451-2: 49423 Da (predicted); Q14451-3: 62064 Da (predicted); Q14451-4: 55920 Da (predicted).
Phosphorylated on serine and threonine residues in response to heregulin

Subunit：Homodimer

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/wi-38-cell.html [Content Brief]