GTF2H3 Antibody (YA8848)
(Synonyms: BTF2; P34; TFB4; TFIIH)GTF2H3 Antibody (YA8848) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GTF2H3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
GTF2H3 Antibody (YA8848) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GTF2H3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 34.2 kDa
Human recombinant protein fragment corresponding to amino acids 1-241 of human GTF2H3 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GTF2H3 component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
Q13889 has two isomers: Q13889-1: 34378 Da (predicted); Q13889-2: 29777 Da (predicted).
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Subunit
Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27193682)
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SwissProt ID
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Synonyms
BTF2; P34; TFB4; TFIIH
Documentation
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