GTF2H3 Antibody (YA8848)

Cat. No.: HY-P89164: Data Sheet User Guide for Antibodies
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GTF2H3 Antibody (YA8848) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GTF2H3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GTF2H3 Antibody (YA8848) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GTF2H3.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 34.2 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q13889

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-241 of human GTF2H3 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q13889 has two isomers: Q13889-1: 34378 Da (predicted); Q13889-2: 29777 Da (predicted).

Subunit：Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27193682)

Synonyms

BTF2; P34; TFB4; TFIIH

Documentation

User Guide for Antibodies (1077 KB)