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HEMGN Antibody (YA8412)(PBS only)

(Synonyms: CT155; EDAG; EDAG-1; NDR)

HEMGN Antibody (YA8412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HEMGN.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • HEMGN Antibody (YA8412)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:100-200

Product Details

Description

HEMGN Antibody (YA8412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HEMGN.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 55.2 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 260-484 of human HEMGN produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    HEMGN regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB)

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_Specificity: Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia
    Induction: Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens

  • Isoforms & Post-Translational Modification

    Q9BXL5: 484 amino acids, molecular weight 55341 Da.

  • SwissProt ID

    Q9BXL5

  • Synonyms

    CT155; EDAG; EDAG-1; NDR

HEMGN Antibody (YA8412)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • HEMGN Antibody (YA8412)(PBS only) Product Image