HMGA2 Antibody (YA1186)
(Synonyms: HMGA2; HMGIC; High mobility group protein HMGI-C; High mobility group AT-hook protein 2)HMGA2 Antibody (YA1186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGA2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
HMGA2 Antibody (YA1186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGA2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 18 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 12 kDa
Recombinant protein of human HMGA2
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HMGA2 functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner[1].
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
P52926 has 6 isomers: P52926-1: 11832 Da (predicted); P52926-2: 11456 Da (predicted); P52926-3: 9273 Da (predicted); P52926-4: 10063 Da (predicted); P52926-5: 10845 Da (predicted); P52926-6: 9742 Da (predicted).
Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2 (By similarity) -
Subunit
Interacts with E4F1 (PubMed:14645522).
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SwissProt ID
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Synonyms
HMGA2; HMGIC; High mobility group protein HMGI-C; High mobility group AT-hook protein 2
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Research Field
Neuroscience
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