HMGCL Antibody (YA7307)
(Synonyms: HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase, HMGCL)
Based on 1 Customer Validation
HMGCL Antibody (YA7307) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGCL.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|
| Dilution Ratio | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
HMGCL Antibody (YA7307) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGCL.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 30 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 34 kDa
A synthesized peptide derived from human HMGCL: 250-300.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HMGCL is a Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism
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Subcellular Localization
Mitochondrion matrix,Peroxisome
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Expression
Tissue_Specificity: Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%) -
Isoforms & Post-Translational Modification
P35914 has three isomers: P35914-1: 34360 Da (predicted); P35914-2: 26910 Da (predicted); P35914-3: 20222 Da (predicted).
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Subunit
Homodimer; disulfide-linked
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SwissProt ID
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Synonyms
HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase, HMGCL
Documentation
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