HNRNPL Antibody (YA7745)

Cat. No.: HY-P88061: Data Sheet User Guide for Antibodies
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HNRNPL Antibody (YA7745) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HNRNPL.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

HNRNPL Antibody (YA7745) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HNRNPL.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 64 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P14866

Immunogen

Human recombinant protein fragment corresponding to amino acids 270-502 of human HNRNPL produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8

Subcellular Localization：Nucleus, nucleoplasm,Cytoplasm

Isoforms & Post-Translational Modification：P14866 has two isomers: P14866-1: 64133 Da (predicted); P14866-2: 50561 Da (predicted).
Several isoelectric forms of the L protein are probably the results of post-translational modifications丨Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization

Subunit：Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661)

Synonyms

hnRNP-L; HNRPL

Documentation

User Guide for Antibodies (1077 KB)