HPS-1 Antibody (YA4895)
(Synonyms: HPS1; HPS; Hermansky-Pudlak syndrome 1 protein)HPS-1 Antibody (YA4895) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HPS-1.
-
Host:
Mouse
-
Application:
WB, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
HPS-1 Antibody (YA4895) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HPS-1.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 79 kDa;
Purified recombinant fragment of HPS-1 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
HPS-1 component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38[1].
-
Expression
Tissue_specificity:Ubiquitous -
Isoforms & Post-Translational Modification
Q92902 has 4 isomers: Q92902-1: 79292 Da (predicted); Q92902-2: 75877 Da (predicted); Q92902-3: 36476 Da (predicted); Q92902-4: 76937 Da (predicted).
-
Subunit
Component of the biogenesis of lysosome-related organelles complex-3 (or BLOC-3), a heterodimer of HPS1 and HPS4 (PubMed:20048159, PubMed:23084991). HPS1 cannot but BLOC-3 complex (heterodimer of HPS1 and HPS4) can interact with the GTP-bound form of RAB9A and RAB9B. HPS1 and BLOC-3 complex do not interact with the GDP-bound form of RAB9A and RAB9B (PubMed:20048159)
-
SwissProt ID
-
Synonyms
HPS1; HPS; Hermansky-Pudlak syndrome 1 protein
Documentation
Powered by Bioz
