HPS-1 Antibody (YA4895)

Cat. No.: HY-P85203: Data Sheet User Guide for Antibodies
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HPS-1 Antibody (YA4895) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HPS-1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

HPS-1 Antibody (YA4895) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HPS-1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 79 kDa;

Species Reactivity

Human

SwissProt ID

Q92902

Gene ID

3257 [NCBI]

Immunogen

Purified recombinant fragment of HPS-1 expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991)

Expression：
Tissue_specificity:Ubiquitous

Isoforms & Post-Translational Modification：Q92902 has 4 isomers: Q92902-1: 79292 Da (predicted); Q92902-2: 75877 Da (predicted); Q92902-3: 36476 Da (predicted); Q92902-4: 76937 Da (predicted).

Subunit：Component of the biogenesis of lysosome-related organelles complex-3 (or BLOC-3), a heterodimer of HPS1 and HPS4 (PubMed:20048159, PubMed:23084991). HPS1 cannot but BLOC-3 complex (heterodimer of HPS1 and HPS4) can interact with the GTP-bound form of RAB9A and RAB9B. HPS1 and BLOC-3 complex do not interact with the GDP-bound form of RAB9A and RAB9B (PubMed:20048159)

Synonyms

HPS1; HPS; Hermansky-Pudlak syndrome 1 protein

Documentation

User Guide for Antibodies (1077 KB)