ICT1 Antibody (YA8673)
(Synonyms: DS-1; DS1; ICT1; MRP-L58)ICT1 Antibody (YA8673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICT1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
ICT1 Antibody (YA8673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICT1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 23.4 kDa
Full length human recombinant protein of human ICT1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ICT1 is essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes[1][2].
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Subcellular Localization
Mitochondrion
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Expression
Tissue_Specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells -
Isoforms & Post-Translational Modification
Q14197: 206 amino acids, molecular weight 23630 Da.
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Subunit
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:20186120, PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605)
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SwissProt ID
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Synonyms
DS-1; DS1; ICT1; MRP-L58
Documentation
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