ICT1 Antibody (YA8673)

Cat. No.: HY-P88989: Data Sheet User Guide for Antibodies
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ICT1 Antibody (YA8673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICT1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ICT1 Antibody (YA8673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICT1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 23.4 kDa

Species Reactivity

Human

SwissProt ID

Q14197

Immunogen

Full length human recombinant protein of human ICT1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294)

Subcellular Localization：Mitochondrion

Expression：
Tissue_Specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells

Isoforms & Post-Translational Modification：Q14197: 206 amino acids, molecular weight 23630 Da.

Subunit：Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:20186120, PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605)

Synonyms

DS-1; DS1; ICT1; MRP-L58

Documentation

User Guide for Antibodies (1077 KB)