IL-19/ Interleukin 19 Antibody
(Synonyms: IL19, ZMDA1, Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG.1)
Based on 1 Customer Validation
IL-19/ Interleukin 19 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL-19.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IF-Tissue, ELISA
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:500-200 | 1:10000-20000 | 1:50-200 |
Product Details
IL-19/ Interleukin 19 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL-19.
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Host Rabbit
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Clonality polyclonal
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Species ReactivityHuman, Rat
Synthetic peptide from human protein at AA range: 51-100.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL-19/ Interleukin 19 is a Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3[1][2][3][4].
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Subcellular Localization
Secreted
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Expression
Induction: by DNA damage through pathways mediated by JUN and cGAS-STING leading to production of the cytokines IL1, IL6, and IL8. -
Isoforms & Post-Translational Modification
IL-19/ Interleukin 19 has 3 isoforms, Q9UHD0-1: amino acid length is 177, molecular weight is 20452 Da (predicted); Q9UHD0-2: amino acid length is 215, molecular weight is 24568 Da (predicted); Q9UHD0-3: amino acid length is 207, molecular weight is 23079 Da (predicted).
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SwissProt ID
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Synonyms
IL19, ZMDA1, Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG.1
Documentation
References
[1]. Small SH, et al. Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage-induced cytokine production. Sci Signal. 2021 Dec 21;14(714):eaba2611. [Content Brief]
[2]. Oral HB, et al. Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26. Eur J Immunol. 2006 Feb;36(2):380-8. [Content Brief]
[3]. Parrish-Novak J, et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 2002 Dec 6;277(49):47517-23. [Content Brief]
[4]. Dumoutier L, et al. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol. 2001 Oct 1;167(7):3545-9. [Content Brief]
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