KIAA1524 Antibody (YA7762)
(Synonyms: CIP2A; p90)KIAA1524 Antibody (YA7762) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KIAA1524.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
KIAA1524 Antibody (YA7762) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KIAA1524.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 102 kDa
Human recombinant protein fragment corresponding to amino acids 635-905 of human KIAA1524 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KIAA1524 acts as an inhibitor of protein phosphatase PP2A. Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies. Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei. Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss[1][2][3][4][5].
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Subcellular Localization
Cytoplasm,Chromosome
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Expression
Tissue_Specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level) -
Isoforms & Post-Translational Modification
Q8TCG1 has two isomers: Q8TCG1-1: 102185 Da (predicted); Q8TCG1-2: 84579 Da (predicted).
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Subunit
Homodimer (PubMed:28174209)
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SwissProt ID
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Synonyms
CIP2A; p90
Documentation
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