KIAA1524 Antibody (YA7762)

Cat. No.: HY-P88078: Data Sheet User Guide for Antibodies
FAQs
Technical Support

KIAA1524 Antibody (YA7762) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KIAA1524.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

KIAA1524 Antibody (YA7762) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KIAA1524.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 102 kDa

Species Reactivity

Human

SwissProt ID

Q8TCG1

Immunogen

Human recombinant protein fragment corresponding to amino acids 635-905 of human KIAA1524 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668)

Subcellular Localization：Cytoplasm,Chromosome

Expression：
Tissue_Specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level)

Isoforms & Post-Translational Modification：Q8TCG1 has two isomers: Q8TCG1-1: 102185 Da (predicted); Q8TCG1-2: 84579 Da (predicted).

Subunit：Homodimer (PubMed:28174209)

Synonyms

CIP2A; p90

Documentation

User Guide for Antibodies (1077 KB)