KLF15 Antibody (YA4931)

Cat. No.: HY-P85239: Data Sheet User Guide for Antibodies
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KLF15 Antibody (YA4931) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLF15.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

KLF15 Antibody (YA4931) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLF15.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 44 kDa;

Observed band size: 44 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9UIH9

Gene ID

28999 [NCBI]

Immunogen

Purified recombinant fragment of human KLF15 expressed in E. Coli. The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	Purity	Ascitic Fluid
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in purified antibody in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation

Subcellular Localization：Nucleus

Expression：
Tissue_specificity:It is highly expressed in the liver, skeletal muscle, and kidneys. It is also expressed in cardiomyocytes. Expression is significantly reduced in cardiac tissues with non-ischemic cardiomyopathy and aortic aneurysms, as well as in glomerular diseases. It is not expressed in bone marrow or lymphoid tissues.

Induction:In podocytes, up-regulated by retinoic acid

Subunit：Interacts with MYOCD and EP300

Synonyms

KLF15; KKLF; Krueppel-like factor 15; Kidney-enriched krueppel-like factor

Documentation

User Guide for Antibodies (1077 KB)