KLF15 Antibody (YA4931)
(Synonyms: KLF15; KKLF; Krueppel-like factor 15; Kidney-enriched krueppel-like factor)KLF15 Antibody (YA4931) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLF15.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in purified antibody in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
KLF15 Antibody (YA4931) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLF15.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 44 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 44 kDa
Purified recombinant fragment of human KLF15 expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
Ascitic Fluid
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in purified antibody in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KLF15 transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4. Involved in podocyte differentiation. Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:It is highly expressed in the liver, skeletal muscle, and kidneys. It is also expressed in cardiomyocytes. Expression is significantly reduced in cardiac tissues with non-ischemic cardiomyopathy and aortic aneurysms, as well as in glomerular diseases. It is not expressed in bone marrow or lymphoid tissues.
Induction:In podocytes, up-regulated by retinoic acid -
Subunit
Interacts with MYOCD and EP300
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SwissProt ID
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Synonyms
KLF15; KKLF; Krueppel-like factor 15; Kidney-enriched krueppel-like factor
Documentation
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