KLHDC3 Antibody (YA7068)
(Synonyms: dJ20C7.3 antibody; hPEAS antibody; kelch domain containing 3 antibody; Kelch domain-containing protein 3 antibody; KLDC3_HUMAN antibody; KLHDC3 antibody; PEAS antibody; Protein Peas antibody; RP1-20C7.3 antibody; Testis intracellular mediator protein antibody)KLHDC3 Antibody (YA7068) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KLHDC3.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, IHC-P, ICC/IF
-
Reactivity :
Mouse, Human
-
Formulation:
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:2000-1:5000 | 1:200-1:500 | 1:50-1:200 |
Product Details
KLHDC3 Antibody (YA7068) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KLHDC3.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityMouse, Human
-
Observed Molecular WeightObserved band size: 43 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 43 kDa
Recombinant protein within Human KLHDC3 aa 121-382 / 382.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
KLHDC3 is a Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine. May be involved in meiotic recombination process[1][2][3][4].
-
Subcellular Localization
Cytoplasm
-
Subunit
Component of a CRL2(KLHDC3) complex, also named ECS(KLHDC3) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC3 (PubMed:29775578, PubMed:29779948)
-
SwissProt ID
-
Synonyms
dJ20C7.3 antibody; hPEAS antibody; kelch domain containing 3 antibody; Kelch domain-containing protein 3 antibody; KLDC3_HUMAN antibody; KLHDC3 antibody; PEAS antibody; Protein Peas antibody; RP1-20C7.3 antibody; Testis intracellular mediator protein antibody
Documentation
Powered by Bioz
