KSHV K8a Antibody (YA4606)
(Synonyms: K8)KSHV K8a Antibody (YA4606) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KSHV K8a.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, ICC/IF, ELISA
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Formulation:
Supplied in ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:25-1:50 ELISA: 1:10000 |
Product Details
KSHV K8a Antibody (YA4606) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KSHV K8a.
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Host Mouse
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Clonality Monoclonal
Purified recombinant fragment of KSHV K8α aa 34-199.
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in ascitic fluid containing 0.03% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KSHV K8a is a SUMO E3 ligase that plays a role in viral gene regulation and is essential for viral reactivation. Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 and RB1. Regulates viral gene expression and reactivation and may mediate the SUMOylation of viral promoters in the low methylated 'Lys-9' histone H3 (H3K9me) region which results in a diminution of viral gene expression after reactivation. SUMOylates also host histone lysine demethylase 4A/KDM4A, an essential step for complete enrichment of SUMO-2/3 on the viral genome during viral transactivation and reactivation[1][2][3][4].
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Subunit
Interacts with host HDAC1 and HDAC2, these interactions suppress HDAC activities. Interacts with protein ORF57. Interacts with protein vPK (PubMed:17108053)
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SwissProt ID
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Synonyms
K8
Documentation
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