L3MBTL3 Antibody (YA8183)
(Synonyms: MBT-1; MBT1)L3MBTL3 Antibody (YA8183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to L3MBTL3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:800-1500 |
Product Details
L3MBTL3 Antibody (YA8183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to L3MBTL3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 85.6 kDa
Human recombinant protein fragment corresponding to amino acids 98-319 of human L3MBTL3 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
L3MBTL3 is an Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells[1][2][3].
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
Q96JM7 has two isomers: Q96JM7-1: 88337 Da (predicted); Q96JM7-2: 85757 Da (predicted).
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Subunit
Interacts with RNF2 (By similarity)
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SwissProt ID
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Synonyms
MBT-1; MBT1
Documentation
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