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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. CD223/LAG-3 Antibody (YA6630)

CD223/LAG-3 Antibody (YA6630)

製品番号: HY-P86937
COA User Guide for Antibodies Technical Support

CD223/LAG-3 Antibody (YA6630) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD223/LAG-3.

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容量 価格（税別） 在庫状況 数量
10 μL $96 在庫あり
50 μL $252 在庫あり
100 μL $408 在庫あり
250 μL   お問い合わせ  
or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

CD223/LAG-3 Antibody (YA6630) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD223/LAG-3.
Host

Rabbit
Clonality

Recombinant,Monoclonal
分子量
Predicted band size: 57.4 kDa;
Observed band size: 55/70 kDa (Glycosylation)
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Mouse
SwissProt ID
Gene ID
Immunogen

Recombinant protein within Human LAG-3 aa 1-500 / 525.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:2000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:100
純度 affinity purified. Conjugation Non-conjugated
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:20421648, PubMed:7805750, PubMed:8647185). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:20421648, PubMed:7805750, PubMed:8647185). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185)|May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response
Subcellular Localization：Cell membrane,Secreted
Expression：
Tissue_Specificity: Primarily expressed in activated T-cells and a subset of natural killer (NK) cells
Induction: Expression is induced by interleukin-2 (IL2), interleukin-7 (IL7) and interleukin-12 (IL12A and IL12B) on activated T-cells
Isoforms & Post-Translational Modification：P18627 has two isomers: P18627-1: 57449 Da (predicted); P18627-2: 39103 Da (predicted).
Proteolytically cleaved by ADAM10 and ADAM17 within the connecting peptide region, leading to release of Secreted lymphocyte activation gene 3 protein (sLAG-3)
Subunit：Interacts with MHC class II (MHC-II); selectively recognizes stable complexes of peptide and MHC-II (PubMed:1692078, PubMed:7589152, PubMed:8647185, PubMed:9159144)
Synonyms
CD223 antibody; CD223 antigen antibody; FDC protein antibody; LAG-3 antibody; Lag3 antibody; LAG3_HUMAN antibody; Lymphocyte activating 3 antibody; Lymphocyte activation gene 3 antibody; Lymphocyte activation gene 3 protein antibody; Protein FDC antibody;
ドキュメンテーション

COA (206 KB)

User Guide for Antibodies (1077 KB)

CD223/LAG-3 Antibody (YA6630) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
CD223/LAG-3 Antibody (YA6630)
製品番号:
HY-P86937
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