LIME1 Antibody (YA8724)
(Synonyms: dJ583P15.4; LIME)LIME1 Antibody (YA8724) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LIME1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
LIME1 Antibody (YA8724) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LIME1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 31.1 kDa
Human recombinant protein fragment corresponding to amino acids 30-295 of human LIME1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LIME1 is involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level) -
Isoforms & Post-Translational Modification
Q9H400 has two isomers: Q9H400-1: 31288 Da (predicted); Q9H400-2: 20841 Da (predicted).
Palmitoylation of Cys-28 and Cys-31 is required for raft targeting丨Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins -
Subunit
When phosphorylated in response to BCR activation, interacts with LYN, PIK3R1, PLCG2, and GRB2 (By similarity)
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SwissProt ID
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Synonyms
dJ583P15.4; LIME
Documentation
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