LRRFIP1 Antibody (YA5133)
(Synonyms: LRRFIP1; GCF2; TRIP; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; GC-binding factor 2; TAR RNA-interacting protein)LRRFIP1 Antibody (YA5133) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LRRFIP1.
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Host:
Mouse
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-1:2000 |
Product Details
LRRFIP1 Antibody (YA5133) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LRRFIP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 89 kDa;
Purified recombinant human LRRFIP1 protein fragments expressed in E.coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LRRFIP1 transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_specificity:general expression -
Isoforms & Post-Translational Modification
Q32MZ4 has 4 isomers: Q32MZ4-1: 89253 Da (predicted); Q32MZ4-2: 86404 Da (predicted); Q32MZ4-3: 82689 Da (predicted); Q32MZ4-4: 73060 Da (predicted).
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Subunit
Homodimer. May also form higher oligomers. Interacts with FLII. Interacts with MYD88. Competes with FLII for MyD88-binding, even in the absence of LPS
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SwissProt ID
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Synonyms
LRRFIP1; GCF2; TRIP; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; GC-binding factor 2; TAR RNA-interacting protein
Documentation
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