MAG Antibody (YA9740)
(Synonyms: GMA, MAG, MAG_HUMAN, Myelin associated glycoprotein, Myelin-associated glycoprotein, S MAG, S-MAG, Sialic acid binding Ig like lectin 4A, Sialic acid binding immunoglobulin like lectin 4A, Siglec 4a)MAG Antibody (YA9740) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to MAG.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IF-Tissue, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:200-1000 | 1:2000-5000 | 1-2μg/sample |
Product Details
MAG Antibody (YA9740) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to MAG.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 69 kDa;
Recombinant protein of human MAG (aa 1-536).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MAG is an Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity)
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Subcellular Localization
Cell membrane; Membrane raft
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Expression
Tissue_Specificity: Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures. Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths. Detected in compact myelin (at protein level). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system. -
Isoforms & Post-Translational Modification
MAG has 3 isoforms, P20916-1: amino acid length is 626, molecular weight is 69069 Da (predicted); P20916-2: amino acid length is 582, molecular weight is 63966 Da (predicted); P20916-3: amino acid length is 601, molecular weight is 66224 Da (predicted).N-glycosylated
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Subunit
Monomer and homodimer (By similarity).
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SwissProt ID
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Synonyms
GMA, MAG, MAG_HUMAN, Myelin associated glycoprotein, Myelin-associated glycoprotein, S MAG, S-MAG, Sialic acid binding Ig like lectin 4A, Sialic acid binding immunoglobulin like lectin 4A, Siglec 4a
Documentation
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