MAK Antibody (YA8347)

Cat. No.: HY-P88663: Data Sheet User Guide for Antibodies
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MAK Antibody (YA8347) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAK.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

MAK Antibody (YA8347) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAK.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human, Rat

SwissProt ID

P20794

Immunogen

Human recombinant protein fragment corresponding to amino acids 291-623 of human MAK produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells

Subcellular Localization：Nucleus,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Cytoplasm, cytoskeleton, spindle,Midbody,Cell projection, cilium, photoreceptor outer segment,Photoreceptor inner segment

Expression：
Tissue_Specificity: Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors
Induction: Up-regulated by dihydrotestosterone (DHT) in androgen-sensitive LNCaP prostate cancer cells in a dose-dependent manner. Up-regulation by DHT is transient, reaching maximum levels after 24 hours and decreases slightly after 48 hours

Isoforms & Post-Translational Modification：P20794 has three isomers: P20794-1: 70581 Da (predicted); P20794-2: 73480 Da (predicted); P20794-3: 66345 Da (predicted).
Autophosphorylated

Subunit：Interacts with RP1 (By similarity)

Synonyms

dJ417M14.2; RP62

Documentation

User Guide for Antibodies (1077 KB)