MBNL1 Antibody (YA2601)

製品番号: HY-P82856: データシート COA User Guide for Antibodies
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MBNL1 Antibody (YA2601) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBNL1.

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容量	価格（税別）	在庫状況	数量
20 μL	$146	在庫あり	Estimated Time of Arrival: December 31
50 μL	$222	在庫あり	Estimated Time of Arrival: December 31
100 μL	$360	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

MBNL1 Antibody (YA2601) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBNL1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

分子量

Predicted band size: 42 kDa;

Observed band size: 42 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

Q9NR56

Gene ID

4154 [NCBI]

Immunogen

A synthesized peptide derived from human MBNL1 aa330-388/388.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). Regulates NCOR2 alternative splicing (By similarity)

Subcellular Localization：Nucleus; Cytoplasm; Cytoplasmic granule

Expression：
Tissue_specificity:Highly expressed in cardiac, skeletal muscle and during myoblast differentiation. Weakly expressed in other tissues (at protein level) . Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

Isoforms & Post-Translational Modification：Q9NR56 has 7 isomers: Q9NR56-1: 41817 Da (predicted); Q9NR56-2: 39831 Da (predicted); Q9NR56-3: 33050 Da (predicted); Q9NR56-4: 34211 Da (predicted); Q9NR56-5: 40992 Da (predicted); Q9NR56-6: 37074 Da (predicted); Q9NR56-7: 36992 Da (predicted).

Subunit：Interacts with DDX1 and YBX1. Interacts with HNRNPH1; the interaction in RNA-independent. Interacts with RBPMS; the interaction allows cooperative assembly of RNA-bound stable cell-specific alternative splicing regulatory complexes (PubMed:37548402)

Database

Entrez Gene: 4154 Human ; 56758 Mouse ; 282635 Rat

SwissProt: Q9NR56 Human ; Q9JKP5 Mouse ;

OMIM: 160900 Human

Research Field

Synonyms

EXP; EXP35; EXP40; EXP42; MBNL; MBNL1

ドキュメンテーション

Select Batch:

COA (205 KB)

User Guide for Antibodies (1077 KB)