MCTS1 Antibody (YA7920)
(Synonyms: MCT-1; MCT1)MCTS1 Antibody (YA7920) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MCTS1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
MCTS1 Antibody (YA7920) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MCTS1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 20.4 kDa
Human recombinant protein fragment corresponding to amino acids 1-181 of human MCTS1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MCTS1 is a Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2[1][2][3][4][5][6][7][8][9][10][11].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas
Induction: By DNA damaging agents such as gamma irradiation, adriamycin or taxol in lymphoid cells, but not by stress stimuli such as heat shock. This induction of protein expression does not occur at the RNA level, and does not require new protein synthesis -
Isoforms & Post-Translational Modification
Q9ULC4 has three isomers: Q9ULC4-1: 20555 Da (predicted); Q9ULC4-2: 19229 Da (predicted); Q9ULC4-3: 20550 Da (predicted).
Phosphorylation is critical for stabilization and promotion of cell proliferation -
Subunit
Interacts (via PUA domain) with DENR; the complex regulates translation reinitiation
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SwissProt ID
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Synonyms
MCT-1; MCT1
Documentation
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