MNDA Antibody (YA7850)
(Synonyms: PYHIN3)MNDA Antibody (YA7850) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MNDA.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
MNDA Antibody (YA7850) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MNDA.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 45.7 kDa
Human recombinant protein fragment corresponding to amino acids 37-321 of human MNDA produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MNDA may act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1
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Subcellular Localization
Nucleus,Cytoplasm
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Expression
Tissue_Specificity: Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appears in myeloblast cells in some cases of acute myeloid Leukemia
Induction: Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3 -
Isoforms & Post-Translational Modification
P41218: 407 amino acids, molecular weight 45836 Da.
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Subunit
Participates in a ternary complex with YY1 and the YY1 target DNA element
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SwissProt ID
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Synonyms
PYHIN3
Documentation
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