MTA3 Antibody (YA8999)
(Synonyms: KIAA1266, MTA3, Metastasis-associated protein MTA3)
Based on 1 Customer Validation
MTA3 Antibody (YA8999) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MTA3.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
human
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1000 | 1-2μg per 100-500μg Total protein |
Product Details
MTA3 Antibody (YA8999) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MTA3.
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Host Mouse
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Species Reactivityhuman
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 67 kDa
OMIM: 609050
A synthesized peptide derived from human MTA3.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
MTA3 acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6[1][2][3][4].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_Specificity: Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
Induction: By estrogen. -
Isoforms & Post-Translational Modification
MTA3 has 2 isoforms, Q9BTC8-1: amino acid length is 594, molecular weight is 67504 Da (predicted); Q9BTC8-2: amino acid length is 515, molecular weight is 58814 Da (predicted).
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Subunit
Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5.
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SwissProt ID
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Synonyms
KIAA1266, MTA3, Metastasis-associated protein MTA3
Documentation
References
[1]. Fujita N, et al. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell. 2003 Apr 18;113(2):207-19. [Content Brief]
[2]. Le Guezennec X, et al. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol. 2006 Feb;26(3):843-51. [Content Brief]
[3]. Hoffmeister H, et al. CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. Nucleic Acids Res. 2017 Oct 13;45(18):10534-10554. [Content Brief]
[4]. Fujita N, et al. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell. 2004 Oct 1;119(1):75-86. [Content Brief]
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