Nectin 2 Antibody (YA1196)
(Synonyms: NECTIN2; HVEB, PRR2, PVRL2; CD112; Nectin-2; Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB); Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2)Nectin 2 Antibody (YA1196) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin 2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.295.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
Nectin 2 Antibody (YA1196) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin 2.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 70-80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 58 kDa
Recombinant protein of human Nectin 2
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.295.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nectin 2 is a Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein; (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV)[1][2].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Ubiquitous -
Isoforms & Post-Translational Modification
Q92692 has 2 isomers: Q92692-1: 57742 Da (predicted); Q92692-2: 51359 Da (predicted).
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Subunit
Can form trans-heterodimers with NECTIN3 (By similarity). Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT
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SwissProt ID
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Synonyms
NECTIN2; HVEB, PRR2, PVRL2; CD112; Nectin-2; Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB); Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2
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Research Field
Immunology
Documentation
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