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NECTIN2 - nectin cell adhesion molecule 2 Gene

Also Known as HVEB; PRR2; CD112; PVRL2; PVRR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5819

About NECTIN2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,846,297-44,889,223 (from NCBI)

This gene has 6 transcripts (splice variants), 428 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 24.8), testis (RPKM 23.6) and 25 other tissues.

Summary

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NECTIN2 Products (2)

mRNA	Protein	Name
NM_001042724.2	NP_001036189.1	nectin-2 isoform delta precursor
NM_002856.3	NP_002847.1	nectin-2 isoform alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	9845526	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	9845526	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adhesion of symbiont to host	IDA IDA: Inferred from direct assay	12915581	GOA
involved in coreceptor-mediated virion attachment to host cell	IDA IDA: Inferred from direct assay	12915581	GOA
involved in fusion of virus membrane with host plasma membrane	IDA IDA: Inferred from direct assay	12915581	GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	9845526	GOA
involved in positive regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	26755705	GOA
involved in positive regulation of immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	16831868	GOA
involved in positive regulation of mast cell activation	IMP IMP: Inferred from mutant phenotype	16831868	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	16304049	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP IMP: Inferred from mutant phenotype	12913096	GOA
involved in regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	11602758	GOA
involved in susceptibility to T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	15039383	GOA
involved in susceptibility to natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	12913096	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16831868	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	9845526	GOA
located in membrane	IDA IDA: Inferred from direct assay	12913096	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECTIN2 Protein Structure

V-set

C2-set_2

Ig_2

0
100
200
300
400
500
538 a.a.

Protein Preferred Names	Protein Names
nectin-2	herpesvirus entry protein B

NECTIN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NECTIN2	Q92692	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	NECTIN2	Q92692	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	NECTIN2	Q92692	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	NECTIN2	Q92692	NECTIN3	Homo sapiens	Q9NQS3	SPR	23758976
Intra	NECTIN2	Q92692	NECTIN3	Homo sapiens	Q9NQS3	Protein Array	21982860
Intra	NECTIN2	Q92692	AFDN	Homo sapiens	P55196	Anti Bait CoIP	23750010
Intra	NECTIN2	Q92692	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	NECTIN2	Q92692	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	NECTIN2	Q92692	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	Solution Sedimentation	22902367
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	GMS	22927415
Intra	NECTIN2	Q92692	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	SPR	22902367
Intra	NECTIN2	Q92692	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	GMS	28515320
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	ELISA	23758976
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	Solution Sedimentation	22927415
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	Protein Array	21982860
Intra	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	X-Ray Diffraction	22927415
Intra	NECTIN2	Q92692	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	NECTIN2	Q92692	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NECTIN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7780	Nectin-2/CD112 Protein, Human (HEK293, His)	Q92692-2 (Q32-L360)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72400	Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi)	Q92692-2 (Q32-L360)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73307	Nectin-2/CD112 Protein, Human (HEK293)	Q92692-2/NP_002847.1 (Q32-L360)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78372	Nectin-2/CD112 Protein, Human (HEK293, Fc)	Q92692-2 /NP_002847.1(Q32-L360)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78495	Nectin-2/CD112 Protein, Human (HEK293, His-Avi)	Q92692-2 (Q32-L360)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78920	Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, mFc-Avi)	Q92692-2 (Q32-L360)	≥ 95%, as determined by reducing SDS-PAGE.

NECTIN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81451	Nectin 2 Antibody (YA1196)	IHC-P	Human
HY-P81451A	Nectin 2 Antibody (YA1196)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome	Orofacial Cleft 7 Zlotogora-Ogur Syndrome CLPED1 Ectodermal Dysplasia, Margarita Island Type Ed4 Cleft Lip-Palate-Ectodermal Dysplasia Syndrome Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate Ectodermal Dysplasia 4 Ectodermal Dysplasia Margarita Type Ectodermal Dysplasia, Type 4 Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly Margarita Type Of Ectodermal Dysplasia Zlotogora-Zilberman-Tenenbaum Syndrome Ectd4 Ectodermal Dysplasia 4, Hair/Nail Type EDMI Ectodermal Dysplasia Type 4 Margarita Island Ectodermal Dysplasia Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate Non-Syndromic Orofacial Cleft 7 OFC7 Non-Syndromic Cleft Lip/Palate 7 Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Ovarian Cystic Teratoma
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09175	NECTIN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18105	Nectin2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24579	Nectin2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992428	NTX-1107C	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NECTIN2	RGD	RGD:1309505
Bos taurus	NECTIN2	VGNC	VGNC:52209
Mus musculus	NECTIN2	MGD	MGI:97822
Macaca mulatta	NECTIN2	VGNC	VGNC:75396
Canis familiaris	NECTIN2	VGNC	VGNC:53741
Others	NECTIN2	NCBI