2. Gene
  3. NECTIN2 - nectin cell adhesion molecule 2 Gene

NECTIN2 - nectin cell adhesion molecule 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HVEB; PRR2; CD112; PVRL2; PVRR2

Gene ID: 5819 | Gene type: protein coding

About NECTIN2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,846,297-44,889,223 (from NCBI)

This gene has 6 transcripts (splice variants), 428 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 24.8), testis (RPKM 23.6) and 25 other tissues.

Summary

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NECTIN2 Products(2)

mRNA Protein Name
NM_001042724.2 NP_001036189.1 nectin-2 isoform delta precursor
NM_002856.3 NP_002847.1 nectin-2 isoform alpha precursor

NECTIN2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (38 - 152)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (167 - 248)

Ig_2

Ig_2: Immunoglobulin domain (277 - 336)

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  • 538 a.a.
Protein Preferred Names Protein Names

nectin-2

herpesvirus entry protein B

Recombinant NECTIN2 Proteins

Cat. No. Product Name Accession Purity
HY-P7780 Nectin-2/CD112 Protein, Human (HEK293, His) Q92692-2 (Q32-L360) ≥95%
HY-P71984 Nectin-2/CD112 Protein, Human (329a.a, HEK 293, His) Q92692 (Q32-G360) ≥95%
HY-P72400 Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) Q92692-2 (Q32-L360) ≥95%
HY-P73307 Nectin-2/CD112 Protein, Human (HEK293) Q92692-2/NP_002847.1 (Q32-L360) ≥95%
HY-P73308 Nectin-2/CD112 Protein, Human (360a.a, HEK293, Fc) Q92692 (M1-L360) ≥95%
HY-P73748 Nectin-2/CD112 Protein, Human (360a.a, HEK293, His) Q92692 (M1-L360) ≥95%
HY-P78372 Nectin-2/CD112 Protein, Human (329a.a, HEK293, Fc) Q92692-2 /NP_002847.1(Q32-L360) ≥95%
HY-P78495 Nectin-2/CD112 Protein, Human (HEK293, His-Avi) Q92692 (Q32-L360) ≥95%
HY-P78920 Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, mFc-Avi) Q92692-2 (Q32-L360) ≥95%

Related Diseases

Diseases Alias
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7

Zlotogora-Ogur Syndrome

CLPED1

Ectodermal Dysplasia, Margarita Island Type

Ed4

Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

Ectodermal Dysplasia 4

Ectodermal Dysplasia Margarita Type

Ectodermal Dysplasia, Type 4

Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

Margarita Type Of Ectodermal Dysplasia

Zlotogora-Zilberman-Tenenbaum Syndrome

Ectd4

Ectodermal Dysplasia 4, Hair/Nail Type

EDMI

Ectodermal Dysplasia Type 4

Margarita Island Ectodermal Dysplasia

Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

Non-Syndromic Orofacial Cleft 7

OFC7

Non-Syndromic Cleft Lip/Palate 7

Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Ovarian Cystic Teratoma
Genital Herpes

Herpes Genitalis

Genital Herpes Simplex

Venereal Herpes

Virus-Genital Herpes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09175 NECTIN2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NECTIN2 RGD RGD:1309505
Bos taurus NECTIN2 VGNC VGNC:52209
Mus musculus NECTIN2 MGD MGI:97822
Macaca mulatta NECTIN2 VGNC VGNC:75396
Canis familiaris NECTIN2 VGNC VGNC:53741
Macaca fascicularis NECTIN2 NCBI
Others NECTIN2 NCBI