NIT1 Antibody (YA1401)
(Synonyms: Nitrilase homolog 1)NIT1 Antibody (YA1401) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NIT1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
NIT1 Antibody (YA1401) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NIT1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 36 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 36 kDa
Entrez Gene: 4817 Human ; 27045 Mouse ; 289222 Rat
SwissProt: Q86X76 Human ; Q8VDK1 Mouse ; Q7TQ94 Rat
OMIM: 604618 Human
A synthetic peptide of human NIT1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NIT1 catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells
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Subcellular Localization
Mitochondrion; Cytoplasm
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Expression
Tissue_specificity:Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas -
Isoforms & Post-Translational Modification
Q86X76 has 5 isomers: Q86X76-1: 35896 Da (predicted); Q86X76-2: 31859 Da (predicted); Q86X76-3: 40200 Da (predicted); Q86X76-4: 34323 Da (predicted); Q86X76-5: 26326 Da (predicted).
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SwissProt ID
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Synonyms
Nitrilase homolog 1
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Research Field
Cell Biology
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