NKRF Antibody (YA8844)
(Synonyms: ITBA4; NRF)NKRF Antibody (YA8844) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NKRF.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
NKRF Antibody (YA8844) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NKRF.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
Human recombinant protein fragment corresponding to amino acids 1-296 of human NKRF produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NKRF enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes[1][2].
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Subcellular Localization
Nucleus, nucleolus
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Expression
Tissue_Specificity: Widely and constitutively expressed (PubMed:10562553). Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney (PubMed:10562553) -
Isoforms & Post-Translational Modification
O15226 has two isomers: O15226-1: 77673 Da (predicted); O15226-2: 79496 Da (predicted).
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Subunit
Interacts with NF-kappa-B (PubMed:10562553)
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SwissProt ID
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Synonyms
ITBA4; NRF
Documentation
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